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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 39, No. 4, 2007, pp. 184-186
Bioline Code: ph07045
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 39, No. 4, 2007, pp. 184-186

 en Antitumor activity of biflavonoids from Ouratea   check for this species in other resources and Luxemburgia   check for this species in other resources on human cancer cell lines
Daniel, Juliana Feijó de Souza; Alves, Cassia Cristina Fernandes; Grivicich, Ivana; da Rocha, Adriana Brondani & de Carvalho, Mário Geraldo

Abstract

The biflavones 7,7"-dimethyllanaraflavone (1), agathisflavone (2), and 7"-methylagathisflavone (3) isolated from the leaves of Ouratea   check for this species in other resources and luxenchalcone (4) isolated from the leaves and branches of Luxemburgia   check for this species in other resources , as well as a mixture of 7,7"-dimethyllanaraflavone and 7"-methylagathisflavone, were assayed against HT-29 colon adenocarcinoma, NCl-H460 non-small cell lung carcinoma, MCF-7 breast cancer cell, OVCAR-3 ovarian adenocarcinoma cells, and RXF-393 renal cell carcinoma. The results show significant activities, particularly for 7,7"-dimethyllanaraflavone (IC 50 0.77 ± 0.08, 2.42 ± 0.22, and 2.59 ± 0.32 mg/ml for NCl-H460, MCF-7, and OVCAR-3, respectively), and for 7"-methylagathisflavone (IC 50 values of 4 mg/ml). Luxenchalcone revealed significant cytotoxicity on the five cell lines tested.

Keywords
Antitumor agents, cancer cell lines, biflavonoids, Luxemburgia, Ouratea

 
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