search
for
 About Bioline  All Journals  Testimonials  Membership  News


Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 39, No. 4, 2007, pp. 201-205
Bioline Code: ph07049
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 39, No. 4, 2007, pp. 201-205

 en Protective effect of Kalanchoe pinnata   check for this species in other resources pers. (Crassulaceae   check for this species in other resources ) on gentamicin-induced nephrotoxicity in rats
Harlalka, Gaurav Vijay; Patil, Chandragauda Raosaheb & Patil, Mahesh Ramu

Abstract

Objective : The present study was undertaken to evaluate the aqueous extract of K. pinnata for its protective effects on gentamicin-induced nephrotoxicity in rats.
Materials and Methods : Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of gentamicin 100 mg/kg/day for eight days. Effect of concurrent administration of K. pinnata leaf extract at a dose of 125 mg/kg/day given by intraperitoneal route was determined using serum and urinary creatinine and blood urea nitrogen as indicators of kidney damage. The study groups contained six rats in each group. As nephrotoxicity of gentamicin is known to involve induction of oxidative stress, in vitro antioxidant activity and free radical-scavenging activity of this extract were evaluated.
Result : It was observed that the aqueous extract of K. pinnata leaves significantly protects rat kidneys from gentamicin-induced histopathological changes. Gentamicin-induced glomerular congestion, peritubular and blood vessel congestion, epithelial desquamation, accumulation of inflammatory cells and necrosis of the kidney cells were found to be reduced in the group receiving the leaf extract of K. pinnata along with gentamicin. This extract also normalized the gentamicin-induced increases in urine and plasma creatinine, blood urea and blood urea nitrogen levels. In vitro studies revealed that the K. pinnata leaf extract possesses significant antioxidant as well as oxidative radical scavenging activities.
Conclusion : It is proposed that the nephroprotective effect of the aqueous extract of K. pinnata leaves in gentamicin-induced nephrotoxicity may involve its antioxidant and oxidative radical scavenging activities.

Keywords
Antioxidant, Bryophyllum pinnata, gentamicin, nephrotoxicity

 
© Copyright 2007 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil