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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 40, No. 2, 2008, pp. 64-68
Bioline Code: ph08025
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 40, No. 2, 2008, pp. 64-68

 en Paralytic effect of alcoholic extract of Allium sativum   check for this species in other resources and Piper longum   check for this species in other resources on liver amphistome, Gigantocotyle explanatum   check for this species in other resources
Singh, TU; Kumar, D & Tandan, SK

Abstract

Objective: To investigate the effects of alcoholic extract of Allium sativum   check for this species in other resources and Piper longum   check for this species in other resources on the muscular activity of a parasitic amphistome, Gigantocotyle explanatum   check for this species in other resources .
Materials and Methods: Amphistomes were isometrically mounted to record the spontaneous muscular activity by using Chart 4 software program (Power Lab, AD Instruments, Australia) and to examine the effects of cumulative doses (100, 300, 1000, and 3000 µg/ml) of the plant extracts on the amplitude (g), frequency (per 10 min), and baseline tension (g) of the spontaneous muscular activity of the amphistome.
Results: Alcoholic extract of A. sativum produced significant reduction in the frequency and amplitude of contractile activity of the amphistome at 1000 and 3000 µg/ml bath concentrations. Complete paralysis of the amphistome was observed after 15 min of addition of 3000 µg/ml concentration. Alcoholic extract of P. longum also caused paralysis following 15-20 min exposure of the amphistome to 3000 µg/ml concentration. In both the cases the amphistomes did not recover from paralysis following 2-3 washes.
Conclusion: The observations demonstrate the paralytic effect of alcoholic extract of A. sativum and P. longum on G. explanatum.

Keywords
Alcoholic extract, Allium sativum, Gigantocotyle explanatum, Piper longum, spontaneous muscular activity

 
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Alternative site location: http://www.ijp-online.com

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