The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats

Objective: To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats.
Methods: Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2^nd , 4^th , 5^th , 7^th , 10^th and 15^th week, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis.
Results: The intratesticular testosterone level was significantly (P< 0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P< 0.001) increased by valproate in a time dependent manner.
Conclusion: Valproate causes reversible change in intratesticular testosterone and LDH level.