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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 40, No. 6, 2008, pp. 256-260
Bioline Code: ph08073
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 40, No. 6, 2008, pp. 256-260

 en Antidiabetic activity of flower buds of Michelia champaca check for this species in other resources Linn.
Jarald, E Edwin; Joshi, SB & Jain, DC

Abstract

Objective: To identify the antihyperglycemic activity of various extracts, petroleum ether (60-80 o ), chloroform, acetone, ethanol, aqueous and crude aqueous, of the flower buds of Michelia champaca check for this species in other resources , and to identify the antidiabetic activity of active antihyperglycemic extract. Materials and Methods: Plant extracts were tested for antihyperglycemic activity in glucose overloaded hyperglycemic rats. The effective antihyperglycemic extract was tested for its hypoglycemic activity at two-dose levels, 200 and 400 mg/kg respectively. To confirm its utility in the higher model, the effective extract of M. champaca was subjected to antidiabetic study in alloxan induced diabetic model at two dose levels, 200 and 400 mg/kg respectively. The biochemical parameters, glucose, urea, creatinine, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein, hemoglobin and glycosylated hemoglobin were also assessed in the experimental animals. Results: The ethanolic extract of M. champaca exhibited significant antihyperglycemic activity but did not produce hypoglycemia in fasted normal rats. Apart from this extract, the crude aqueous and petroleum ether extracts were found active only at the end of the first hour. Treatment of diabetic rats with ethanolic extract of this plant restored the elevated biochemical parameters significantly (P< 0.05) (P< 0.01) and the activity was found dose dependent. Conclusion: This study supports the traditional claim and the ethanolic extract of this plant could be added in traditional preparations for the ailment of various diabetes-associated complications.

Keywords
Alloxan, antidiabetic activity, hypoglycemic activity, lipid profile, Michelia champaca

 
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Alternative site location: http://www.ijp-online.com

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