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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 40, No. 6, 2008, pp. 266-270
Bioline Code: ph08075
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 40, No. 6, 2008, pp. 266-270

 en Antioxidant potential of the methanol-methylene chloride extract of Terminalia glaucescens check for this species in other resources leaves on mice liver in streptozotocin-induced stress
Njomen, Guy Bertrand Sabas Nya; Kamgang, Rene; Oyono, Jean Louis Essame & Njikam, Njifutie

Abstract

Aim: The antioxidant effect of the methanol-methylene chloride extract of Terminalia glaucescens check for this species in other resources (Combretaceae) leaves was investigated in streptozotocin (STZ)-induced oxidative stress.
Methods: Oxidative stress was induced in mice by a daily dose of STZ (45 mg/kg body weight i.p.) for five days. From day one, before STZ injection, normal and diabetic-test mice received an oral dose of the extract (100 or 300 mg/kg b.w.) daily. Plasma metabolites, lipid peroxidation, and antioxidant enzymes in the liver were assessed and gain in body weight recorded.
Results: In normal mice the plant extract reduced food and water intake, blood glucose and LDL-C level and body weight gain, did not affect the lipid peroxidation in the liver, while the antioxidant enzyme activities seemed increased. Blood glucose was decreased (P < 0.05) in normal mice treated with 300 mg/kg extract. Diabetic mice pretreated with 100 mg/kg extract as diabetic control mice (DC) showed significant (P < 0.001) body weight loss, polyphagia and polydipsia, high plasma glucose level, decrease in the liver catalase, peroxidase, and superoxide dismutase activities, and increase in lipid peroxidation. The HDL-C level was lowered (P < 0.05) whereas LDL-C increased. In 300 mg/kg extract-pretreated diabetic mice the extract prevented body weight loss, increase of blood glucose level, lipid peroxidation in liver, food and water intake, and lowering of plasma HDL-C level and liver antioxidants; this extract prevented LDL-C level increase.
Conclusion: These results indicate that T. glaucescens protects against STZ-induced oxidative stress and could thus explain its traditional use for diabetes and obesity treatment or management.

Keywords
Antioxidant enzymes, diabetes mellitus, malondialdehyde, Terminalia glaucescens

 
© Copyright 2008 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com

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