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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 40, No. 6, 2008, pp. 271-275
Bioline Code: ph08076
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 40, No. 6, 2008, pp. 271-275

 en Gastroprotective effect of Benincasa hispida check for this species in other resources fruit extract
Rachchh, Manish A & Jain, Sunita M

Abstract

Objectives: The antiulcer activity of Benincasa hispida (Thunb.) Cogn. fruit was evaluated in rats against ethanol-induced gastric mucosal damage, pylorus ligated (PL) gastric ulcers, and cold restraint-stress (CRS)-induced gastric ulcer models.
Methods: Petroleum ether and methanol extracts were administrated orally at the dose of 300 mg/kg, and omeprazole (reference standard) at the dose of 20 mg/kg. Ulcer index was common parameter studied in all the models. Further, vascular permeability was evaluated in ethanol model, and effect on lipid peroxidation, viz. melondialdehyde (MDA) content, superoxide dismutase (SOD), and catalase (CAT) levels were studied in CRS model.
Results: Both the extracts produced significant reduction in ulcer index (P < 0.05) in all the models and the results were comparable with that of omeprazole-treated group. Further, significant reduction in vascular permeability (P < 0.05) was observed. In CRS model, MDA content was significantly reduced along with increase in CAT levels as compared to control group.
Conclusions: Petroleum ether and methanol extracts of B. hispida possess significant antiulcer as well as antioxidant property.

Keywords
Antiulcer, antioxidant, ulcer index, vascular permeability

 
© Copyright 2008 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com

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