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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 41, No. 2, 2009, pp. 75-79
Bioline Code: ph09022
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 41, No. 2, 2009, pp. 75-79

 en Screening of Bauhinia purpurea check for this species in other resources Linn. for analgesic and anti-inflammatory activities
Shreedhara, CS; Vaidya, VP; Vagdevi, HM; Latha, KP; Muralikrishna, KS & Krupanidhi, AM

Abstract

Objectives: Ethanol extract of the stem of Bauhinia purpurea check for this species in other resources Linn. was subjected to analgesic and anti-inflammatory activities in animal models.
Materials and Methods: Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic activity (determined by Eddy′s hot plate method and acetic acid writhing method) and anti-inflammatory activity determined by carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of Bauhinia purpurea Linn. (BP) at the dose level of 50mg/kg and 100mg/kg.
Results: The analgesic and anti-inflammatory activities of ethanol extracts of BP were significant (P < 0.001). The maximum analgesic effect was observed at 120 min at the dose of 100mg/kg (i.p.) and was comparable to that of standard analgin (150mg/kg) and the percentage of edema inhibition effect was 46.4% and 77% for 50mg/kg and 100mg/kg (i.p) respectively. Anti-inflammatory activity was compared with standard Diclofenac sodium (5mg/kg).
Conclusion: Ethanol extract of Bauhinia purpurea has shown significant analgesic and anti-inflammatory activities at the dose of 100 mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.

Keywords
Analgesic activity, anti-inflammatory activity, Bauhinia purpurea Linn, eddy′s hot plate

 
© Copyright 2009 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com

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