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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 1998-3751
Vol. 42, No. 2, 2010, pp. 70-73
Bioline Code: ph10023
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 42, No. 2, 2010, pp. 70-73

 en A study of the antidiabetic activity of Barleria prionitis check for this species in other resources Linn
Dheer, Reema & Bhatnagar, Pradeep

Abstract

Objectives: To study the antidiabetic activity of Barleria prionitis check for this species in other resources Linn in normal and alloxan-induced diabetic rats. Materials and Methods: Alcoholic extract of leaf and root of B. prionitis was tested for their antidiabetic activity. Albino rats were divided into six groups of six animals each. In three groups, diabetes was induced using alloxan monohydrate (150 mg/kg b.w., i.p.) and all the rats were given different treatments consisting of vehicle, alcoholic extract of leaves, and alcoholic extract roots of B. prionitis Linn (200 mg/kg) for 14 days. The same treatment was given to the other three groups, comprising non-diabetic (normal) animals. Blood glucose level, glycosylated hemoglobin, liver glycogen, serum insulin, and body weight were estimated in normal and alloxan-induced diabetic rats, before and 2 weeks after administration of drugs. Results: Animals treated with the alcoholic extract of leaves of B. prionitis Linn showed a significant decrease in blood glucose level (P< 0.01) and glycosylated hemoglobin (P< 0.01). A significant increase was observed in serum insulin level (P< 0.01) and liver glycogen level (P< 0.05), whereas the decrease in the body weight was arrested by administration of leaf extract to the animals. The alcoholic extract of roots showed a moderate but non-significant antidiabetic activity in experimental animals. Conclusion: The study reveals that the alcoholic leaf extract of B. prionitis could be added in the list of herbal preparations beneficial in diabetes mellitus.

Keywords
Barleria prionitis, alloxan monohydrate, alcoholic extract

 
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Alternative site location: http://www.ijp-online.com

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