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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 1998-3751
Vol. 42, No. 2, 2010, pp. 82-86
Bioline Code: ph10026
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 42, No. 2, 2010, pp. 82-86

 en The antiepileptic effect of Centella asiatica check for this species in other resources on the activities of Na + /K + , Mg 2+ and Ca 2+ -ATPases in rat brain during pentylenetetrazol-induced epilepsy
Visweswari, G.; Siva Prasad, K.; Lokanatha, V. & Rajendra, W.

Abstract

Background: To study the anticonvulsant effect of different extracts of Centella asiatica check for this species in other resources (CA) in male albino rats with reference to Na + /K + , Mg 2+ and Ca 2+ -ATPase activities.

Materials and Methods: Male Wistar rats (150±25 g b.w.) were divided into seven groups of six each i.e. (a) control rats treated with saline, (b) pentylenetetrazol (PTZ)-induced epileptic group (60 mg/kg, i.p.), (c) epileptic group pretreated with n-hexane extract (n-HE), (d) epileptic group pretreated with chloroform extract (CE), (e) epileptic group pretreated with ethyl acetate extract (EAE), (f) epileptic group pretreated with n-butanol extract (n-BE), and (g) epileptic group pretreated with aqueous extract (AE).

Results: The activities of three ATPases were decreased in different regions of brain during PTZ-induced epilepsy and were increased in epileptic rats pretreated with different extracts of CA except AE.

Conclusion: The extracts of C. asiatica, except AE, possess anticonvulsant and neuroprotective activity and thus can be used for effective management in treatment of epileptic seizures.

Keywords
Anticonvulsant effect, ATPases, Centella asiatica, epilepsy, pentylenetetrazol

 
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Alternative site location: http://www.ijp-online.com

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