search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 1998-3751
Vol. 42, No. 2, 2010, pp. 90-94
Bioline Code: ph10028
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 42, No. 2, 2010, pp. 90-94

 en Reproductive toxicity of sodium valproate in male rats
Bairy, Laxminarayana; Paul, Vijay & Rao, Yeshwanth

Abstract

Objectives: To assess the effects of sodium valproate on rat sperm morphology, sperm count, motility, and histopathological changes in testis.

Materials and Methods: Male Wistar rats (12 week old) were treated with sodium valpraote and sacrificed at the end of 2 nd , 4 th , 5 th , 7 th , 10 th and 15 th week after the last exposure to sodium valproate. Epididymal sperm count, sperm motility, sperm morphology, and histopathology of testes were analyzed.

Results: Sperm count and sperm motility were decreased significantly by sodium valproate. The percentage of abnormal sperms increased in a dose-dependent manner. A histopathological study revealed that sodium valproate had caused sloughing of epithelial cells in testes.

Conclusion: Sodium valproate causes reversible change in sperm motility, sperm count, morphology, and cytoarchitecture of testes.

Keywords
Cytoarchitecture of testis, sodium valproate, sperm count, sperm morphology, sperm motility

 
© Copyright 2010 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2020, Site last up-dated on 07-Jul-2020.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil