Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
Vol. 42, No. 3, 2010, pp. 129-134
Bioline Code: ph10041
Full paper language: English
Document type: Symposium
Document available free of charge
Indian Journal of Pharmacology, Vol. 42, No. 3, 2010, pp. 129-134
© Copyright 2010 Indian Journal of Pharmacology.
Animal models and biomarkers of neuropathy in diabetic rodents|
Shaikh, A. S. & Somani, R. S.
Diabetic neuropathy (DN) is a multifactor complication of diabetes. It is a late finding in type 1 diabetes, but can be an early finding in type 2 diabetes. The cause of DN is still unclear and, like other complications of diabetes, it may be the result of various pathological conditions. Animal models and biomarkers of DN have been extensively used in neuropathic research. The most useful model of DN should exhibit the key feature present in human pathology. Diabetic rodents show behavioral, functional, structural and molecular biomarkers and they are widely used as models to investigate the etiology of DN as well as to screen the efficacy of the potential therapeutic interventions. We have reviewed the different animal models and biomarkers of neuropathy in diabetic rodents of either type 1 or type 2 diabetes.
Biomarker, diabetic neuropathy, diabetic rodents
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