search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 1998-3751
Vol. 42, No. 3, 2010, pp. 146-149
Bioline Code: ph10044
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 42, No. 3, 2010, pp. 146-149

 en Effect of centchroman coadministration on the pharmacokinetics of metformin in rats
Lal, Jawahar & Jain, Girish K.

Abstract

Objectives : To study the effect of centchroman, a non-steroidal oral contraceptive, coadministration on the pharmacokinetics of metformin in rats.
Materials and Methods : The pharmacokinetic interaction of metformin was studied in normal Sprague-Dawley female rats with and without centchroman coadministration. Blood samples were analyzed using a validated high-performance liquid chromatography method to generate the pharmacokinetic profile of metformin. The C max and t max were directly read from the concentration-time data. Other pharmacokinetic parameters were estimated using non-compartmental analyses.
Results : Metformin was monitored up to 10 h, and it exhibited a double-peak phenomenon. The C max 1, 2.62 ± 0.32 μg/ml, and C max 2, 2.96 ± 0.65 μg/ml, occurred after 0.75 and 3 h post-dose, respectively. The mean residence time (MRT), AUC 0-4 h and volume of distribution (Vd/F) were 4.20 ± 0.30 h, 8.53 ± 1.89 μg.h/ml and 14.24 ± 5.42 L/kg, respectively. Following centchroman coadministration, metformin showed significantly (P < 0.05) higher C max (C max 1, 3.96 ± 0.55 μg/ml and C max 2, 5.21 ± 0.59 μg/ml), AUC 0-4 h (12.28 ± 0.73 μg.h/ml) and Vd/F (18.29 ± 1.19 L/kg), but lower MRT (3.19 ± 0.36 h) than the values obtained after metformin dosing alone. However, AUC0-t (17.74 ± 5.58 μg.h/ml) and clearance (3.76 ± 0.80 L/h/kg) remained unchanged.
Conclusions : The results indicate that centchroman coadministration increases the rate but not the extent of absorption of metformin in rats. However, it does not seem to alter the pharmacokinetics of metformin to clinically significant levels.

Keywords
Centchroman, drug interaction, metformin, oral antidiabetic, oral contraceptive

 
© Copyright 2010 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2020, Site last up-dated on 28-Nov-2020.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil