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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 42, No. 6, 2010, pp. 384-387
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Bioline Code: ph10111
Full paper language: English
Document type: Research Article
Document available free of charge
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Indian Journal of Pharmacology, Vol. 42, No. 6, 2010, pp. 384-387
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Effect of l-ornithine l-aspartate against thioacetamide-induced hepatic damage in rats
Najmi, Abul K.; Pillai, K. K.; Pal, S. N.; Akhtar, M.; Aqil, M. & Sharma, M.
Abstract
Objective: To investigate the hepatoprotective activity of L-ornithine-L-aspartate against thioacetamide (TAA)-induced hepataopathy in rats.
Materials and Methods: The hepatoprotective activity of L-ornithine-L-aspartate (OA) at a dose of 2 g/kg, p.o. for 10 days was evaluated against TAA (250 mg/kg, i.p. for 2 days) induced hepatopathy in rats. Biochemical parameters such as serum aspartate transaminase, alanine transaminase, alkaline phosphatase, bilirubin and glutathione, thiobarbituric acid reactive substances, and protein in liver tissues were estimated to assess the liver function.
Results: TAA-induced pathogenic changes in the levels of the above indices were significantly (P < 0.01) reversed by the OA treatment. OA treatment also exhibited significant restoration of the hepatic architecture and lobular structure in histological evaluation of the rat liver sections.
Conclusion: Ornithine aspartate exhibited significant hepatoprotective activity against TAA-induced hepatic damage in rats.
Keywords
Hepatopathy, ornithine aspartate, oxidative stress, thioacetamide
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© Copyright 2010 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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