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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 42, No. 6, 2010, pp. 392-396
Bioline Code: ph10113
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 42, No. 6, 2010, pp. 392-396

 en The study of aqueous extract of Pterocarpus marsupium check for this species in other resources Roxb. on cytokine TNF-α in type 2 diabetic rats
Halagappa, Kirana; Girish, H. N. & Srinivasan, B. P.

Abstract

Objective: This study was designed to investigate the effect of aqueous extract of Pterocarpus marsupium Roxb. on elevated inflammatory cytokine, tumor necrosis factor (TNF)-α in type 2 diabetic rats.
Materials and Methods: Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in a neonatal rat model. Aqueous extract of P. marsupium at a dose of 100 and 200 mg/kg was given orally to desired group of animals for a period of 4 weeks. After 4 weeks of drug treatment, parameters such as fasting blood glucose, postprandial blood glucose, and TNF-α in serum were analyzed.
Results: Aqueous extract of P. marsupium at both doses, i.e., 100 and 200 mg/kg, decreased the fasting and postprandial blood glucose in type 2 diabetic rats. The 200 mg/kg had more pronounced effect on postprandial hyperglycemia. The drug also improved the body weight of diabetic animals. Cytokine TNF-α was found to be elevated in untreated diabetic rats due to chronic systemic inflammation. The aqueous extract at both doses significantly (P < 0.001) decreased the elevated TNF-α level in type 2 diabetic rats.
Conclusion: Modulation of cytokine TNF-α by the rasayana drug P. marsupium is related with its potential anti-diabetic activity.

Keywords
Cytokine, Pterocarpus marsupium, TNF-α, Type 2 diabetes

 
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