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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 42, No. 6, 2010, pp. 397-400
Bioline Code: ph10114
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 42, No. 6, 2010, pp. 397-400

 en Evaluation of hepatoprotective activity of Cissus quadrangularis check for this species in other resources stem extract against isoniazid-induced liver damage in rats
Swamy, A.H.M. Viswanatha; Kulkarni, Rucha V.; Thippeswamy, A.H.M.; Koti, B. C. & Gore, Aparna

Abstract

Objective: The study was designed to investigate the hepatoprotective activity of methanol extract of Cissus quadrangularis (CQ) against isoniazid-induced hepatotoxicity in rats.
Materials and Methods: The successive petroleum ether (60-80°C) and methanol extracts of C. quadrangularis were used. Hepatic damage was induced in Wistar rats by administering isoniazid (54 mg/kg, p.o.) once daily for 30 days. Simultaneously, CQ (500 mg/kg p.o) was administered 1 h prior to the administration of isoniazid (54 mg/kg, p.o.) once daily for 30 days. Silymarin (50 mg/kg p.o) was used as a reference drug.
Results: Elevated levels of aspartate transaminase, alanine transaminase, alkaline posphatase, and bilirubin following isoniazid administration were significantly lowered due to pretreatment with CQ. Isoniazid administration significantly increased lipid peroxidation (LPO) and decreased antioxidant activities such as reduced glutathione, superoxide dismutase, and catalase. Pretreatment of rats with CQ significantly decreased LPO and increased the antioxidant activities.
Conclusion: The results of this study indicated that the hepatoprotective effect of CQ might be attributed to its antioxidant property.

Keywords
Antioxidant activity, Cissus quadrangularis, hepatotoxicity, isoniazid

 
© Copyright 2010 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com

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