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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 42, No. 6, 2010, pp. 412-415
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Bioline Code: ph10118
Full paper language: English
Document type: Short Communication
Document available free of charge
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Indian Journal of Pharmacology, Vol. 42, No. 6, 2010, pp. 412-415
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Therapeutic misadventure with paracetamol in children
Shivbalan, So; Sathiyasekeran, Malathi & Thomas, Kuruvilla
Abstract
Paracetamol (acetaminophen), though considered a safe, "over the counter" analgesic and antipyretic, can cause liver injury with overdose. Therapeutic misadventure is a unique problem where the existing nomogram used for acute poisoning is not applicable. In this context, early initiation of N-acetylcysteine even before a biochemical evidence of liver injury may be beneficial. A series of 6 children with this type of paracetamol overdose are presented here to increase the awareness and understanding of this problem since no such data is available from India.
Keywords
Acetaminophen, NAC, N-acetylcysteine, paracetamol, poisoning, therapeutic misadventure, toxicity
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© Copyright 2010 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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