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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 43, No. 1, 2011, pp. 31-35
Bioline Code: ph11008
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 43, No. 1, 2011, pp. 31-35

 en Protective role of Phyllantus niruri check for this species in other resources extract in doxorubicin-induced myocardial toxicity in rats
Thippeswamy, A.H.M.; Shirodkar, Akshay; Koti, B.C.; Sadiq, A. Jaffar; Praveen, D.M.; Swamy, A.H.M. Viswanatha & Patil, Mahesh

Abstract

Objectives : To investigate the effect of the aqueous extract of Phyllantus niruri check for this species in other resources (Aq.E.PN) against doxorubicin (Dox)-induced myocardial toxicity in rats.
Materials and Methods : Cardiotoxicity was produced by Dox administration (15 mg/kg for 2 weeks). Aq.E PN (200 mg/kg, orally) was administered as pretreatment for 2 weeks alternated with Dox for the next 2 weeks. The general observations, mortality, histopathology, biomarker enzymes like lactate dehydrogenase (LDH), creatinine phosphokinase (CPK) and alkaline phosphatase, diagnostic enzyme markers like aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and antioxidants such as glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) were monitored after 3 weeks of the last dose.
Results : Pretreatment with the Aq.E.PN significantly (P < 0.01) protected the myocardium from the toxic effects of Dox by reducing the elevated level of biomarker and diagnostic enzymes like LDH, CPK, AST and ALT to the normal levels. Aq.E PN increased the GSH, SOD and CAT levels and decreased the MDA levels in cardiac tissue. Administration of Dox caused cardiomyopathy associated with an antioxidant deficiency.
Conclusion : These results suggest a cardioprotective effect of P. niruri due to its antioxidant properties.

Keywords
Phyllanthus niruri, antioxidant, cardiotoxicity, doxorubicin

 
© Copyright 2011 Indian Journal of Pharmacology.
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