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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 43, No. 1, 2011, pp. 80-81
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Bioline Code: ph11020
Full paper language: English
Document type: Special Article
Document available free of charge
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Indian Journal of Pharmacology, Vol. 43, No. 1, 2011, pp. 80-81
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Methylphenidate-induced mania-like symptoms
Chakraborty, Kaustav & Grover, Sandeep
Abstract
Therapeutic dose of methylphenidate is known to cause adverse effects (psychosis or mania), albeit in a small number of cases. Signs and symptoms of adverse effects usually disappear on stopping the medicine. Data regarding the safety of methylphenidate in comorbid attention deficit hyperactivity disorder (ADHD) and mental retardation are nonexistent. We describe a case of an 11-year-old girl with ADHD and mental retardation treated with methylphenidate, who developed mania like symptoms requiring inpatient treatment. The index case required psychopharmacological intervention with sodium valproate and olanzapine as the symptoms did not subside even after 3 days. This case highlights the fact that one has to exercise caution while prescribing methylphenidate in patients with comorbid ADHD and mental retardation.
Keywords
Adverse drug effect, attention deficit hyperactivity disorder, mental retardation, Methylphenidate, psychosis/mania
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© Copyright 2011 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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