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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 43, No. 2, 2011, pp. 172-175
Bioline Code: ph11045
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 43, No. 2, 2011, pp. 172-175

 en Comparison of sublingual, vaginal, and oral misoprostol in cervical ripening for first trimester abortion
Parveen, Shagufta; Khateeb, Zaffar Abbas; Mufti, S.M.; Shah, M.A.; Tandon, Vishal R.; Hakak, S.; Singh, Z.; Yasmeen, Shagufta; Mir, Shakeel A.; Tabasum, Rehana & Jan, Nasreen


Objectives : To compare the effectiveness and tolerability of misoprostol as a cervical ripening agent in first trimester abortion through three different routes of administration before surgical evacuation (SE).
Materials and Methods : It was a hospital based prospective randomized open labeled parallel study. A total of 150 randomly selected married women were divided in three groups for sublingual (S/L), vaginal and oral 400 μg of misoprostol single dose administration. The drug was administered 3-4 h before SE in the S/L and vaginal groups and 12 h before the procedure in the oral group. Efficacy was assessed on the basis of time taken for ripening, dilatation achieved, duration of the procedure, intra-operative blood loss, and pain score. The tolerability was noted on the basis of side effects.
Results : The mean time taken for cervical ripening was less in sublingual administration (3.7±1.2 hr) as compared to the vaginal and oral routes. The S/L group had significant cervical dilatation (P<0.001) and the duration of SE was less as compared to the vaginal and oral routes. However, the mean intraoperative blood loss was more in sublingual as compared to the vaginal and oral groups. The intra-operative pain score of the S/L group was significantly lower (1.9±1.1, P<0.05) as compared to the vaginal (2.6±1.7) or oral route (3.3±1.7). Loose motions and nausea/vomiting were more with the S/L and oral routes while blood loss was more in the vaginal route.
Conclusion : Administration of misoprostol by the sublingual route is better than the oral and vaginal routes for cervical ripening.

Cervical ripening, first trimester abortion, misoprostol, surgical evacuation

© Copyright 2011 Indian Journal of Pharmacology.
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