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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 43, No. 2, 2011, pp. 210-211
Bioline Code: ph11055
Full paper language: English
Document type: Special Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 43, No. 2, 2011, pp. 210-211

 en IFN-α-2a (Interferon) and ribavirin induced suicidal attempt in a patient of chronic HCV: A rare case report
Inder, Deep; Rehan, H.S.; Yadav, Madhur; Manak, Seema & Kumar, Pawan

Abstract

Interferons (IFNs) are proteins produced by cells, fibroblasts and macrophages, in response to viral invasion, and mediates immune response. IFN-α and ribavirin are the approved treatment for HCV infection, but also carries a risk of neuropsychiatric adverse effects, viz. insomnia, irritability, mood changes, and depression.
We present a case report of depression induced by IFN-α and ribavirin, leading to attempted suicide. Following the episode, antidepressant paroxetine (20 mg o.d.) and zolpidem (10 mg h.s) were added with psychotherapy. No significant improvement was observed. Patient was given a drug dechallenge (IFN-α and ribavirin). Dramatic improvement was seen over 1 month. Following rechallenge with combination, patient again experienced depressive symptoms with suicidal ideation. IFN-α and ribavirin were promptly stopped. Naranjo causality assessment scale revealed probable association with IFN-α and ribavirin. The report intends to improve awareness among clinicians to facilitate early diagnosis and intervention of similar cases.

Keywords
Adverse effects, depression, IFN-α, ribavirin

 
© Copyright 2011 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com

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