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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 43, No. 4, 2011, pp. 393-397
Bioline Code: ph11107
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 43, No. 4, 2011, pp. 393-397

 en Evaluation of the anti-inflammatory activity of Aegle marmelos check for this species in other resources (Bilwa) root
Benni, Jyoti M.; Jayanthi, M. K. & Suresha, R. N.

Abstract

Aims and objectives: The purpose of this study was to evaluate and compare the anti-inflammatory activity of the aqueous root bark extract of Aegle marmelos check for this species in other resources (Bilwa) in experimental acute and chronic inflammatory animal models.
Materials and Methods: Aqueous extract of root bark of Bilwa was prepared and tested for anti-inflammatory activity in albino rats weighing 150-280 grams. The animals were randomly divided into 3 groups of 6 each; one group served as control and other two groups received indomethacin and Bilwa orally 1 hour prior to experimentation. The in vivo anti-inflammatory activity was studied using the acute (Carrageenan induced paw edema) and chronic (Cotton pellet induced granuloma) animal models. Anti-inflammatory activity was expressed as Percent inhibition (PI). Statistical analysis was performed using One-way analysis of variance (ANOVA) followed by Scheffe′s post hoc test. P < 0.05 was considered statistically significant.
Results: The PI with indomethacin and Bilwa in carrageenan induced paw edema were 52.7% and 46% and in cotton pellet induced granuloma were 24.7% and 9.2% respectively. Indomethacin showed highly significant anti-inflammatory activity in both the models. However, Bilwa showed highly significant activity in acute model and but a trend of anti-inflammatory activity in chronic model studied.
Conclusions: As Bilwa showed significant anti-inflammatory activity in the models studied, it can be a promising anti-inflammatory agent.

Keywords
Aegle marmelos; anti-inflammatory; carrageenan; granuloma; edema

 
© Copyright 2011 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com

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