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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 2, No. 1, 2003, pp. 123-124
Bioline Code: pr03001
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 2, No. 1, 2003, pp. 123-124

 en Editorial - Bioinformatics and drug target selection for malaria control
Raphael D. Isokpehi

Abstract

The use of antimalarial drugs is an important component of malaria control programmes. These drugs class broadly into quinolines, artemisinins, antifolates, atovaquone/proguanil and antibiotics. The effectiveness of drugs is increasingly compromised by resistance. The development of new antimalarials and improvement of existing ones is therefore crucial to reduction of the increasing disease burden and economic loss due to malaria. Publication of the genome sequences of the most virulent human malaria parasite, Plasmodium falciparum check for this species in other resources and a rodent parasite, P. yoelii yoelii open new opportunities for intensive research to identify critical parasite determinants encoded in the genomes that can serve as drug targets and candidates for drug discovery programmes. The future availability of genome sequences of primate and other human and rodent malaria parasites will permit comparative analysis and open the ability to test the efficacy of drugs in robust model systems prior to clinical trials.

 
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Alternative site location: http://www.tjpr.org

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