Some excipients are currently available for the formulation of pharmaceutical suspensions. The purpose of this study is to search for a cheap and effective natural excipient that can be used as an effective alternative for the formulation of pharmaceutical suspensions.
The suspending properties of Albizia zygia
gum (family Mimosoideae) were evaluated comparatively with those of Compound Tragacanth, Acacia and Gelatin at concentration range of 0.5 - 4.0%w/v in Sulphadimidine suspension. Characterization tests were carried out on purified Albizia zygia
gum. Sedimentation volume (%), rheology and particle size analysis were employed as evaluation parameters. The values obtained therefrom were used as basis for comparison of the suspending agents studied.
Results: Albizia zygia
gum is devoid of alkaloids, anthraquinones and carbohydrates which ensures its "inertness". Albizia zygia
gum (2.5%w/v) produced a comparable suspending ability as 4%w/v Compound Tragacanth. Also, the suspending ability of all the materials was found to be in the order: Albizia zygia
> Compound Tragacanth gum > Acacia gum > Gelatin. At all concentrations employed, Albizia zygia
gum had the strongest suspending ability relative to the other materials.
The results suggest that, due to the high viscosity of Albizia zygia
gum, its mucilage can be a stabilizer of choice when high viscosity is desired. It can also serve as a good thickening agent in both pharmaceutical and food industries.