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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 3, No. 1, 2004, pp. 279-284
Bioline Code: pr04003
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 3, No. 1, 2004, pp. 279-284

 en Evaluation of the suspending properties of Albizia zygia check for this species in other resources gum on sulphadimidine suspension
Mbang N Femi-Oyewo, Musiliu O Adedokun and Taiwo O Olusoga

Abstract

Purpose: Some excipients are currently available for the formulation of pharmaceutical suspensions. The purpose of this study is to search for a cheap and effective natural excipient that can be used as an effective alternative for the formulation of pharmaceutical suspensions.
Method: The suspending properties of Albizia zygia check for this species in other resources gum (family Mimosoideae) were evaluated comparatively with those of Compound Tragacanth, Acacia and Gelatin at concentration range of 0.5 - 4.0%w/v in Sulphadimidine suspension. Characterization tests were carried out on purified Albizia zygia gum. Sedimentation volume (%), rheology and particle size analysis were employed as evaluation parameters. The values obtained therefrom were used as basis for comparison of the suspending agents studied.
Results: Albizia zygia gum is devoid of alkaloids, anthraquinones and carbohydrates which ensures its "inertness". Albizia zygia gum (2.5%w/v) produced a comparable suspending ability as 4%w/v Compound Tragacanth. Also, the suspending ability of all the materials was found to be in the order: Albizia zygia > Compound Tragacanth gum > Acacia gum > Gelatin. At all concentrations employed, Albizia zygia gum had the strongest suspending ability relative to the other materials.
Conclusion: The results suggest that, due to the high viscosity of Albizia zygia gum, its mucilage can be a stabilizer of choice when high viscosity is desired. It can also serve as a good thickening agent in both pharmaceutical and food industries.

Keywords
Albizia zygia, suspending agents, sedimentation volume, rheology, particle size.

 
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Alternative site location: http://www.tjpr.org

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