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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 4, No. 1, 2005, pp. 341-347
Bioline Code: pr05003
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 4, No. 1, 2005, pp. 341-347

 en Antioxidant and antimicrobial activities of Heracleum nepalense check for this species in other resources D Don root
Suvakanta Dash, Lila Kanta Nath, Satish Bhise and Nihar Bhuyan

Abstract

Purpose: The aim of the present study was to investigate antioxidant and antimicrobial effects of the methanol extract of Heracleum nepalense check for this species in other resources D.Don roots.
Method: The antimicrobial effect was determined by agar dilution and disc diffusion method. The free radical scavenging potential was studied by using different antioxidants models of screening using vitamin E (5mM) as standard.
Results: The crude methanol extract of H.nepalense root was found to be active against both Gram-positive and Gram-negative organisms. The ethyl acetate soluble fraction of the extract showed similar activity against these organisms. Similarly, the methanol extract at 1000 μg. ml-1 and the ethyl acetate fraction at 50 μg. ml-1 exhibited significant antioxidant activity in ferrous sulphate induced lipid peroxidation, 1,1- diphenyl- 2-picryl hydrazyl (DPPH), Hydroxyl radical and Superoxide scavenging models.
Conclusions: The study confirms the possible antioxidant and antimicrobial potentiality of the plant extract. Presence of flavonoid alone or in combination with its other components could be responsible for the activity.

Keywords
Heracleum nepalense, Lipid peroxidation, Superoxide scavenging, DPPH assay, Antimicrobial effect, Flavonoid.

 
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