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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 6, No. 3, 2007, pp. 773-778
Bioline Code: pr07019
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 6, No. 3, 2007, pp. 773-778

 en In Vitro Evaluation of Antimicrobial Activity of Crude Extract from Plants Diospyros peregrina check for this species in other resources , Coccinia grandis check for this species in other resources and Swietenia macrophylla check for this species in other resources
Dewanjee, S.; Kundu, M.; Maiti, A.; Majumdar, R.; Majumdar, A. & Mandal, S.C.


Purpose: The aim of the present study was to investigate antimicrobial activity of methanol extract of Diospyros peregrina fruits (MEDP), Coccinia grandis leaves (MECG) and Swietenia macrophylla barks (MESM).
Methods: MEDP, MECG and MESM were examined against some selective gram positive and gram negative bacterial (20) and fungal (4) strains. Preliminary antimicrobial activity was evaluated by agar disc diffusion method. Minimum inhibitory concentration was determined by tube dilution (MIC) whilst minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were determined by agar diffusion method.
Results: MEDP and MESM both have shown highest sensitivity against Escherichia coli strains. MEDP was found resistant to Sarcina luteus and Bacillus spp whereas MESM was resistant to all Shigella strains. MECG has shown major activity against Staphylococcus aureus, Escherichia coli, Shigella dysenteriae, Shigella soneii and Pseudomonas aeruginosa; whilst resistant to Shigella flexneri and Shigella boydii. Against fungi strains extracts were found effective at higher concentrations. Candida albicans has shown highest sensitivity whilst Penicillium spp. was least effective to all three extracts.
Conclusion: The study confirms that MEDP, MECG, MESM all possess antimicrobial activity with different potency against variety of selected microorganisms. The differentiating activities of these three extracts encourage developing a novel broad spectrum antimicrobial herbal formulation in future.

Diospyros peregrina, Coccinia grandis, Swietenia macrophylla, Antimicrobial activity, Ciprofloxacin, Griseofulvin.

© Copyright 2007. TJPR Faculty of Pharmacy, University of Benin, Benin City, Nigeria
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