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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 6, No. 3, 2007, pp. 779-783
Bioline Code: pr07020
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 6, No. 3, 2007, pp. 779-783

 en Antibacterial activity of the aqueous extract of Thonningia sanguinea check for this species in other resources against Extended-Spectrum-β-Lactamases (ESBL) producing Escherichia coli check for this species in other resources and Klebsiella pneumoniae check for this species in other resources strains
N'guessan, J.D.; Dinzedi, M.R.; Guessennd, N.; Coulibaly, A.; Dosso, M.; Djaman, A.J. & Guede-Guina, F.

Abstract

Purpose: The aim of this study was to evaluate the antimicrobial activity of Thonningia sanguinea against two sensitive and two multi-drug resistant (ESBL) Enterobacteria strains namely Escherichia coli and Klebsiella pneumoniae.
Method: The confirmation of the ESBL producing strains was done by the double-disc synergy tests and the broth dilution method was used for the determination of the antimicrobial parameters (MIC and MBC) on these sensitive and ESBL producing strains.
Results: The two sensitive strains had the same MIC and MBC values respectively 3.125 mg /ml and 12.50 mg/ml. The ESBL producing strains also had the same MIC of 6.25 mg /ml and MBC values of 25 mg/ml. The extract was bactericidal for all tested strains.
Conclusion: The results suggest that the flowers of T. sanguinea can be used in association with antibiotics for alternative therapy of diseases caused by ESBL producing E .coli, K. pneumoniae.

Keywords
antimicrobial activity, Thonningia sanguinea, ESBL producing strains; E .coli.

 
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