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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 7, No. 1, 2008, pp. 907-912
Bioline Code: pr08006
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 7, No. 1, 2008, pp. 907-912

 en Anti-ulcer and Anti-inflammatory Effects of Hydroalcohol Extract of Aloe buettneri check for this species in other resources A. Berger (Lilliaceae)
Metowogo, K.; Agbonon, A.; Eklu-Gadegbeku, K.; Aklikokou, A.K. & Gbeassor, M.

Abstract

Purpose: Aloe buettneri check for this species in other resources A. Berger is commonly used in Togolese folk medicine to treat inflammation and gastric ulcer. In this study we investigated the anti-oedema, analgesic, antipyretic and ulcer healing properties of the hydro-alcohol extract of their leaves.
Methods: Rat oedema paw were induced by the injection of 0.1 ml of formaldehyde 1%, tail flick method is used to study analgesic property, hyperthermia was induced by subcutaneous injection of 15% of a brewers' yeast suspension at dose of 10 ml/kg and ulcers were induced by ethanol or HCl/ethanol mixture.
Results: The extract showed anti-inflammatory properties at doses between 250-500 mg/kg. It inhibited, in a dose- dependent manner, the oedema induced by 0.1 ml of formaldehyde 1%. Scores of 73.70% and 83.63% were obtned when the doses of extract administered were 100 and 500 mg/kg, respectively. The tail flick analgesic index showed an increase of 36.56% when the dose was 500 mg/kg. The extract decreased significantly the hyperthermia induced by the injection of yeast. 1000 mg/kg of the extract inhibited 63.77% of the gastric lesion induced by acid-water-ethanol mixture while daily administration of the same dose accelerated the cicatrisation of gastric ulcer induced by 95% ethanol.
Conclusion: The results obtained show that the hydro-alcohol extract of Aloe buettneri A. Berger (Lilliaceae) has anti-inflammatory, anti-ulcer and wound healing properties

Keywords
Aloe buettneri, oedema, analgesic, hyperthermia, ulcer.

 
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