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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 7, No. 3, 2008, pp. 1025-1031
Bioline Code: pr08023
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 7, No. 3, 2008, pp. 1025-1031

 en Diversity of Urinary Tract Pathogens and Drug Resistant Isolates of Escherichia Coli in different age and gender Groups of Pakistanis
Bashir, M.F.; Qazi, J.I.; Ahmad, N. & Riaz, S.

Abstract

Purpose: This paper was mainly aimed to investigate drug resistance of the various urinary tract infection (UTI) pathogens from patients of different gender and age groups of Pakistanis.
Method: For these purposes, urine samples of 109 patients were analyzed. Samples were screened on CLED agar. Antimicrobial susceptibility testing was performed by Kirby Bauer's disc diffusion method. Isolated colonies were processed for biochemical characterization and antibiotic sensitivity to ampicillin, amikacin, augmentin, ceftazidime, ceftriaxone, cefuroxime, cotrimoxazole, ciprofloxin, imipenem, meropenem, tazocine, trimethoprim, gentamicin and nitrofuratoin.
Result: E.Coli was found to be the most frequent causative agent of UTIs (66%) followed by Enterococci check for this species in other resources (8.3%), Candida check for this species in other resources spp. and Pseodomonas check for this species in other resources spp. (7.3% each), Klebsiella check for this species in other resources spp. (5.5%) and Enterobacter check for this species in other resources spp. (2.7%). Proteus check for this species in other resources . and Morgenella check for this species in other resources species were found in less than 1% of the cases. E. coli showed variable antimicrobial resistance to different antibiotics as 92%, 86%, 80%, 62%, 47%, 20% and 4% of the isolates were found to be resistant to ampicillin, cotrimoxazole, ciprofloxin, gentamicin, nitrofuratoin and amikacin, respectively.
Conclusion: The most effective in vitro agents were found to be amikacin followed by gentamicin (among the parenterals), and ciprofloxin among the orally administratered ones. A higher prevalence of UTIs was observed in the female population and E.coli showed no resistance to nitrofuratoin in age groups of 50+ and 70+ in both genders.

Keywords
Urinary tract infections, Age, Gender, Resistant microbes, E.coli.

 
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