Purpose:
The ethanol extracts obtained from the leaves, rootstock and the combined formulation of endemic
Salvia tigrina
Hedge & Hub.-Mor. (Labiatea) have been investigated for their antifungal activities.
Method:
The antifungal activity of the extract was tested against
Candida
species (
C. albicans ATCC 10231,
C. tropicalis ATCC 13803 and
C. guilliermondii ATCC 6260 and
Cryptococcus
species (
C. neoformans ATCC 90112 and
C. laurentii 34142),
Aspergillus flavus
,
Penicillium frequentans
,
Botrytis cinerea
,
Geotrichum candidum
,
Fusarium oxysporum
and
Alternaria alternara
by the visual broth macrodilution method. Ketoconazole was used as a positive reference standard to determine the sensitivity of the strains.
Results:
The minimum inhibitory concentration (MIC) ranged from 3.12 to 25 mg/mL. All the extracts exhibited a strong antifungal effect against the fungal cultures. The extracts exhibited greater antifungal effect against
C. albicans,
C. neoformans and
B. cinarea.
Conclusion:
The findings provide support for the use of this plant in traditional medicine for fungal infections especially against candidiasis.
