The ethanol extracts obtained from the leaves, rootstock and the combined formulation of endemic Salvia tigrina
Hedge & Hub.-Mor. (Labiatea) have been investigated for their antifungal activities.
The antifungal activity of the extract was tested against Candida
species (C. albicans
ATCC 10231, C. tropicalis
ATCC 13803 and C. guilliermondii
ATCC 6260 and Cryptococcus
species (C. neoformans
ATCC 90112 and C. laurentii
34142), Aspergillus flavus
, Penicillium frequentans
, Botrytis cinerea
, Geotrichum candidum
, Fusarium oxysporum
and Alternaria alternara
by the visual broth macrodilution method. Ketoconazole was used as a positive reference standard to determine the sensitivity of the strains.
The minimum inhibitory concentration (MIC) ranged from 3.12 to 25 mg/mL. All the extracts exhibited a strong antifungal effect against the fungal cultures. The extracts exhibited greater antifungal effect against C. albicans
, C. neoformans
and B. cinarea
The findings provide support for the use of this plant in traditional medicine for fungal infections especially against candidiasis.