search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 8, No. 2, 2009, pp. 117-125
Bioline Code: pr09016
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 8, No. 2, 2009, pp. 117-125

 en Anticonvulsant Activity of Carissa carandas check for this species in other resources Linn. Root Extract in Experimental Mice
Hegde, Karunakar; Thakker, Shalin P.; Joshi, Arun B.; Shastry, C.S. & Chandrashekhar, K.S.

Abstract

Purpose: The aim of the present study was to investigate anticonvulsant effect of the ethanolic extract of the roots of Carissa carandas check for this species in other resources (ERCC) on electrically and chemically induced seizures.
Methods: The ethanolic extract of the roots of C. carandas (100, 200 and 400 mg/kg, i.p.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and pentylenetetrazole-, picrotoxin-, bicuculline-and N-methyl-dl-aspartic acid-induced seizures in mice. The latency of tonic convulsions and the number of animals protected from tonic convulsions were noted.
Results: ERCC (100-400 mg/kg) significantly reduced the duration of seizures induced by maximal electroshock (MES). However, only 200 and 400mg/kg of the extract conferred protection (25 and 50%, respectively) on the mice. The same doses also protected animals from pentylenetetrazole-induced tonic seizures and significantly delayed the onset of tonic seizures produced by picrotoxin and N-methyl-dl-aspartic acid. The extract had no effect on bicuculline-induced seizures.
Conclusion: The data suggest that the ethanolic root extract of C. carandas may produce its anticonvulsant effects via non-specific mechanisms since it reduced the duration of seizures produced by maximal electroshock as well as delayed the latency of seizures produced by pentylenetetrazole and picrotoxin.

Keywords
Carissa carandas, Ethanol extract, Anticonvulsant activity, Convulsion, Seizures, Mice.

 
© © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Alternative site location: http://www.tjpr.org

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2022, Site last up-dated on 19-Jan-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil