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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 8, No. 4, 2009, pp. 331-336
Bioline Code: pr09043
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 8, No. 4, 2009, pp. 331-336

 en Antipyretic and Analgesic Effects of the Aqueous Extract of the Fruit Pulp of Hunteria umbellata check for this species in other resources K Schum (Apocynaceae)
Igbe, Ighodaro; Ozolua, Raymond I; Okpo, Steve O & Obasuyi, Osahon

Abstract

Purpose: The aqueous fruit pulp extract of Hunteria umbellata check for this species in other resources K. Schum is used traditionally for the treatment of various fevers. The purpose of this study was to evaluate the extract for antipyretic and analgesic activity, and determine its probable mechanism of action.
Methods: Pyrexia was induced in rabbits by intravenous injection of 105 CFU of E. coli/kg. Rectal temperature was monitored at 30, 60, and 90 min post-administration of 250 and 500 mg/kg of the extract. The analgesic effect of the extract was evaluated using acetic acid-induced mouse writhing test. The extract was tested for antimicrobial activity against Staphylococcus aureus check for this species in other resources , Klebsiella pnuemoniae check for this species in other resources , Escherichia coli check for this species in other resources , and Psuedomonas aeruginosa check for this species in other resources using agar diffusion method. Phytochemical screening of the plant extract was also carried out.
Results: Phytochemical screening revealed the presence of simple sugars, saponins, flavonoids, alkaloids and steroidal compounds. The extract (250, 500 mg/kg) and aspirin produced comparable antipyretic effects up to 60 min. The extract did not inhibit the growth of the microorganisms but significantly reduced the number of writhes in mice at 250 and 500 mg/kg with results comparable to ASA.
Conclusion: The extract possesses antipyretic and analgesic activities which validate its use in the treatment of pains and fevers.

Keywords
Hunteria umbellata; Anti-pyrexic; Analgesic; Antibacterial effect

 
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