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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 8, No. 4, 2009, pp. 371-375
Bioline Code: pr09048
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 8, No. 4, 2009, pp. 371-375

 en Antimicrobial Activity of the Leaves of Endemic Stachys pseudopinardii check for this species in other resources in Turkey
Dulger, G & Aki, C

Abstract

Purpose: The ethanol extract of the leaves of Stachys pseudopinardii check for this species in other resources R. Bhattacharjee and Hub.–Mor. (Lamiaceae) were investigated for their antimicrobial activities.
Methods: The antimicrobial activity of the leaf extract of the plant was tested against Bacillus subtilis check for this species in other resources ATCC 6633, Bacillus cereus check for this species in other resources ATCC 7064, Staphylococcus aureus check for this species in other resources ATCC 6538P, Escherichia coli check for this species in other resources ATCC 10538, Proteus vulgaris check for this species in other resources ATCC 6899, Salmonella typhimurium check for this species in other resources CCM 5445 and Pseudomonas aeruginosa check for this species in other resources ATCC 27853, as well as Candida albicans check for this species in other resources ATCC 10239, Debaryomyces hansenii check for this species in other resources DSM 70238, Kluyveromyces fragilis check for this species in other resources ATCC 8608 and Rhodotorula rubra check for this species in other resources DSM 70403, by disc diffusion and microdilution methods. Selected antibacterial agents (penicillin, tobramycin and ampicillin) and antifungal agents (nystatin, clotrimazole and ketoconazole) antibiotics were used as positive reference standards in the tests.
Results: The extracts showed strong antibacterial activity against Bacillus cereus check for this species in other resources ATCC 7064, with an inhibition zone of 25.0 mm, and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 16 and 32 µg/mL, respectively. Debaryomyces hansenii DSM 70238 was among the most susceptible of the yeast cultures, with an inhibition zone of 17.0 mm and MIC and minimum fungicidal concentration (MFC) of 32 and 32 µg/mL, respectively. The extract exhibited moderate activity against the other test microorganisms.
Conclusion: The results demonstrate that the ethanol extract of the leaves of Stachys pseudopinardii has significant antimicrobial activity and suggest that it may be useful in the treatment of infections.

Keywords
Stachys pseudopinardii, ethanol extract, antimicrobial activity, MIC, MBC, MFC

 
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