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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 8, No. 5, 2009, pp. 393-398
Bioline Code: pr09051
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 8, No. 5, 2009, pp. 393-398

 en Hypoglycemic Effects of Clitoria ternatea check for this species in other resources Linn. (Fabaceae) in Alloxan-induced Diabetes in Rats
Daisy, P. & Rajathi, M.

Abstract

Purpose: This study aims to investigate the therapeutic effects of the aqueous extract of Clitoria ternatea check for this species in other resources Linn. Fabaceae leaves and flowers on alloxan-induced diabetes in rats.
Methods: The effect of orally administered aqueous extracts (400 mg/kg body weight) of Clitoria ternatea leaves and flowers on serum glucose, glycosylated hemoglobin, and insulin were examined in control and extract-treated diabetic rats. The glycogen content of the liver and skeletal muscles of the rats was evaluated while the activities of the glycolytic enzyme, glucokinase, and the gluconeogenic enzyme, glucose-6-phosphatase in the liver were assessed. The extracts were administered over a period of 84 days.
Results: The aqueous extracts of Clitoria ternatea leaves and flowers significantly (P<0.05) reduced serum glucose, glycosylated hemoglobin and the activities of gluconeogenic enzyme, glucose-6- phosphatase, but increased serum insulin, liver and skeletal muscle glycogen and the activity of the glycolytic enzyme, glucokinase. For all the biochemical tests performed, the leaf extract-treated rat showed essentially the same profile as those treated with the flower extract.
Conclusion: The present investigation suggests that Clitoria ternatea leaf and flower extracts exhibit antihyperglycaemic effect in rats with alloxan-induced diabetes mellitus.

Keywords
Alloxan, Diabetes mellitus, Clitoria ternatea, Blood glucose, Glucose-6-phosphatase, Glucokinase, Glycogen

 
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