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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 8, No. 6, 2009, pp. 509-514
Bioline Code: pr09065
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 8, No. 6, 2009, pp. 509-514

 en Effect of Feronia elephantum check for this species in other resources (Corr) Fruit Pulp Extract on Indomethacin-induced Gastric Ulcer in Albino Rats
Mishra, Anurag; Arora, Sandeep; Gupta, Rajiv; Manvi; Punia, Rajesh Kumar & Sharma, Ashish Kumar

Abstract

Purpose: To investigate the activity of Feronia elephantum check for this species in other resources fruit pulp extract (which is used in folk medicine) against indomethacin-induced gastric ulcer in rats.
Methods: The fruit pulp was extracted with ethanol and the anti-ulcer activity of the extract in indomethacin-induced gastric ulceration in Swiss albino rats was evaluated. The parameters assessed were pH and acid concentration of gastric contents, and gastric ulcer index. Ranitidine was used as the reference anti-ulcer drug. Acute toxicity studies were also carried out.
Results: The extract (500 mg/kg, p.o.) inhibited indomethacin-induced gastric ulceration by decreasing acid concentration of gastric fluid while elevating its pH (p < 0.01), and compared well with the standard drug, ranitidine (p < 0.001). However, its anti-ulcer activity was not as potent as that of ranitidine. Acute toxicity studies showed that there was no mortality following the administration of the extract in a dose range of 250 - 5000 mg/kg, p.o..
Conclusion: Feronia elephantum fruit pulp extract has potent antiulcer activity with low toxicity. Its anti-ulcer property probably acts via a reduction in gastric acid secretion. The results obtained support the use of this herbal material in folk medicine.

Keywords
Anti-ulcer; Feronia elephantum (Corr.); Indomethacin; Ulcer; Gastric acidity

 
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