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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 9, No. 2, 2010, pp. 165-171
Bioline Code: pr10020
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 9, No. 2, 2010, pp. 165-171

 en Antimicrobial Activity of 23 Endemic Plants in Madagascar
Rakotoniriana, Erick Francisco; Rajaonarison, Jean François; Raoelison, Emmanuel Guy; Rajaonarivelo, Jacob Philémon; Manga, Nia; Solofoniaina, Marcellin; Rakotonirina, Benja; Randriamampionona, Denis; Rabemanantsoa, Christian; Cheuk, Kiban; Urveg-Ratsimamanga, Suzanne & Leclercq, Joëlle Quetin

Abstract

Purpose: To screen the crude methanol extracts obtained from 23 endemic plants in Madagascar for antimicrobial activity.

Methods: In order to assess the antimicrobial properties of the extracts, their minimum inhibitory concentrations (MICs) were obtained using the broth microdilution method. The six test pathogenic species used were Bacillus subtilis check for this species in other resources , Staphylococcus aureus check for this species in other resources , Escherichia coli check for this species in other resources , Salmonella typhi check for this species in other resources , Pseudomonas aeruginosa check for this species in other resources and Candida albicans check for this species in other resources . Bioautography agar overlay test and phytochemical screening were also performed on the most active extracts.

Results: From the 23 plants tested, 16 of which are used in traditional medicine, Poivrea phaneropetala check for this species in other resources (Combretaceae), Koehneria madagascariensis check for this species in other resources (Lythraceae) and Rhopalopilia perrieri check for this species in other resources (Opiliaceae) exhibited the broad spectrum of activity, being active against all the test organisms, while Monoporus clusiifolius check for this species in other resources (Myrsinaceae) showed the strongest antifungal activity against Candida albicans with a minimal inhibitory concentration of 0.250 mg/ml. Bioautography and phytochemical analysis of the five active extracts against bacterial strains and of one active extract against C. albicans indicate that the active compounds responsible for antimicrobial activity may be mainly flavonoids and/or terpenes.

Conclusion: These preliminary results are the first antimicrobial studies on these plants and lend support for the use of some of them in traditional medicine.

Keywords
Antimicrobial properties, Traditional medicine, Microdilution assay, Bioautography, Madagascar

 
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