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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 9, No. 2, 2010, pp. 187-195
Bioline Code: pr10023
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 9, No. 2, 2010, pp. 187-195

 en Microencapsulation of Diclofenac Sodium by Non-solvent Addition Technique
Murtaza, G.; Ahmad, M. & Shahnaz, G.

Abstract

Purpose: To prepare, using non-solvent addition technique, diclofenac sodium-ethylcellulose microparticles with modified drug release properties.

Methods: Microparticles were prepared by non-solvent addition phase separation method and characterized by micromeritics, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), x-ray diffraction (XRD), dissolution test and thermal analysis.

Results: The microparticles were whitish, irregular, aggregated, and in the size range of 390 - 442 ìm size. Drug embedment efficiency was 89 - 91 %. Characterisation studies indicate that there was no strong chemical interaction between the drug and the polymer in the microparticles. Polymer concentration and sustained release behavior were directly proportional.

Conclusion: Non-solvent addition phase separation is a suitable method for preparing diclofenac sodium-ethylcellulose multi-unit controlled release drug delivery system.

Keywords
Phase separation, Diclofenac sodium, Ethylcellulose, Non-solvent addition, Characterisation

 
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