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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 9, No. 4, 2010, pp. 329-337
Bioline Code: pr10039
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 9, No. 4, 2010, pp. 329-337

 en Effect of cream formulation of fenugreek seed extract on some mechanical parameters of human skin
Akhtar, N.; Waqas, M.K.; Ahmed, M.; Saeed, T.; Murtaza, G.; Rasool, A.; Aamir, M.N.; Khan, S.A.; Bhatti, N.S. & Ali, A.

Abstract

Purpose: To determine the effect of an emulsion formulation of fenugreek ( Trigonella Foneum-Graecum check for this species in other resources L) seed extract on some mechanical parameters of the skin of healthy human volunteers
Methods: A water-in-oil emulsion cream base without fenugreek seed extract which served as control, and a similar formulation containing 4 %w/v of the extract in the internal (aqueous) phase were prepared. Each of the formulations was applied to the cheeks of 10 human volunteers for a period of 4 weeks and some mechanical parameters (R0, R1, R2, R3, R4, R5, R6, R7, R8 and R9) of the skin were measured weekly using Cutometer MPA 580.
Results: The results indicate that the effects of the creams on skin mechanical properties were significant (p < 0.05) with respect to time, except for R4 and R9. The extract-containing cream substantially increased skin elasticity, hydration and the ability of skin to resist photo-aging when compared to the base.
Conclusion: Both the cream base and the cream containing fenugreek extract demonstrated significant (p < 0.05) improvement in all mechanical parameters related to skin elasticity, ageing, hydration and fatigue but the effect of the extract cream was more pronounced in some cases.

Keywords
Cutometer, Fenugreek seed extract, Skin elasticity, Skin ageing, Skin hydration

 
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