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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 9, No. 5, 2010, pp. 455-462
Bioline Code: pr10054
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 9, No. 5, 2010, pp. 455-462

 en In Vitro Antitumour Activity of Sesamum indicum Linn Flower Extracts
Xu, Hua; Wen, Yong-ping; Zhao, Wen & He, Qing

Abstract

Purpose: To investigate the antitumour activity of Sesamum indicum L.
Methods All the fractions of the ethanol extract of Sesamum indicum L. were obtained by solvent refining technique. Methyl thiazolyl tetrazolium (MTT) method was used to test the cytotoxicity of the extracts on four different tumour cell lines - Hela, CNE-2, smmc-7721 and Kyse-410. The effect of Sesamum indicum L. on apoptosis and cell cycle of tumour cells was analyzed by flow cytometry.
Results The petroleum benzene fraction and diethyl ether fraction showed significant antitumour activity compared with the control (P<0.05). Typical hypodiploid apoptotic peak was demonstrated in tumour cells treated by petroleum benzene fraction. The diethyl ether fraction evidently influenced the cell cycle of the tumour cells.
Conclusion The petroleum benzene and diethyl ether fractions of Sesamum indicum L. may contain antitumour components. The mechanism of inhibition of tumour cells may be linked to cytotoxic activity and apoptotic induction.

Keywords
Sesamum indicum L.; Anti-tumour activity; MTT method; Flow cytometry.

 
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