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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 9, No. 5, 2010, pp. 475-481
Bioline Code: pr10057
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 9, No. 5, 2010, pp. 475-481

 en In Vitro Antimicrobial Activities of Cicer arietinum L (Chickpea)
Kan, A.; Özçelik, B.; Kartal, M.; Özdemir, Z.A. & Özgen, S.

Abstract

Purpose: To evaluate the antibacterial and antifungal activities of the extracts of the seed, fruit skin and aerial parts of ten registered varieties of Cicer arietinum (Chickpea)
Method: Susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) and used an inhibition endpoint for determination of the minimum inhibition concentration (MIC). The tests were carried out by microdilution method against standard strains of E. coli, P. aeruginosa, K. pneumoniae, S. aureus, B. subtilis, and E. faecalis for their antibacterial activity using ampicillin and oflaxocin as reference standards, and against C. albicans with ketocanazole and flukonazole as reference standards for antifungal activity.
Results: Chickpea seed extracts (Cse) showed antibacterial activity against Gram-negative strains (E. coli, P. aeruginosa and K. pneumoniae) in the concentration range of 16–64 μg ml-1 but were less active (concentration of 64 μg ml-1) against Gram-positive strains (S. aureus, B. subtilis and E. faecalis) .
Conclusion: This is the first report showing that C. arietinum extracts has substantial antifungal activity at a concentration as low as 8 μg ml-1

Keywords
Antibacterial; Antifungal; Cicer arietinum; Chickpea

 
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