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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 9, No. 5, 2010, pp. 499-503
Bioline Code: pr10060
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 9, No. 5, 2010, pp. 499-503

 en Spectrophotometric Determination of Cilostazol in Tablet Dosage Form
Basniwal, Pawan Kumar; Kumar, Vinesh; Shrivastava, Prabhat Kumar & Jain, Deepti

Abstract

Purpose: To develop simple, rapid and selective spectrophotometric methods for the determination of cilostazol in tablet dosage form.
Methods: Cilostazol was dissolved in 50 % methanol and its absorbance was scanned by ultraviolet (UV) spectrophotometry. Both linear regression equation and standard absorptivity were calculated and both methods were validated as per ICH guidelines. Cilostazol was determined in tablet dosage form using these validated methods.
Results: The λmax of cilostazol was 258.2 nm in 50 % methanol. Beer-Lambert’s law was obeyed in the concentration range of 0 – 25 μg/ml and standard absorptivity was 420.2 dL.g-1.cm-1 . The numerical values for all the validation parameters were within acceptable limits. The results of cilostazol tablet determination by linear regression equation and standard absorptivity methods indicate purity of 100.0 - 102.4 and 98.7 - 101.1 % with standard deviations of 0.611 and 0.592, respectively. Comparing the methods at 99 % confidence limit, the F-test value was found to be 1.065.
Conclusion: These validated methods may be useful for routine analysis of cilostazol as bulk drugs, in dosage forms as well as in dissolution studies in the pharmaceutical industry.

Keywords
ilostazol tablets, UV spectrophotometry, Linear regression equation, Standard absorptivity.

 
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