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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 10, No. 4, 2011, pp. 393-401
Bioline Code: pr11049
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 10, No. 4, 2011, pp. 393-401

 en Grewia Gum 2: Mucoadhesive Properties of Compacts and Gels
Nep, Elijah I & Conway, Barbara R

Abstract

Purpose: To compare the mucoadhesive performance of grewia polysaccharide gum with those of guar gum, carboxymethylcellulose, hydroxypropyl methylcellulose and carbopol 971P.
Methods: Grewia polysaccharide gum compacts or gels as well as those of guar gum, carboxymethylcellulose, hydroxypropyl methylcellulose or carbopol 971P were prepared. Texturometric and tensile analysis of the polymer gels and compacts were carried out using a software-controlled penetrometre, TA.XTPlus texture analyzer. The polymer gels were evaluated for hardness, stickiness, work of cohesion and work of adhesion. Furthermore, the detachment force of the polymer compacts from a mucin substrate was evaluated.
Results: The work of adhesion of guar gels was significantly greater than that of grewia gels (p<0.001) but the latter showed a significantly greater work of adhesion than carboxymethylcellulose gels (p<0.05) and hydroxypropyl methylcellulose gels (p<0.001). However, the work of cohesion for grewia/mucin gel mixture was significantly greater (p<0.001) than those of carboxymethylcellulose/mucin, hydroxypropyl methylcellulose/mucin and carbopol 971P/mucin gel blends. The difference between the mucoadhesive performance of grewia compacts and those of hydroxypropyl methylcellulose and carbopol 971P compacts was insignificant (p>0.05).
Conclusion: Grewia polysaccharide gum demonstrated good mucoadhesive properties, comparable to those of carbopol 971P, carboxymethylcellulose, guar gum and hydroxypropyl methylcellulose, and therefore, should be suitable for the formulation of retentive drug delivery devices.

Keywords
Grewia polysaccharide gum, Texture analyzer, Mucoadhesive performance, Work of cohesion/adhesion

 
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