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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 10, No. 5, 2011, pp. 603-609
Bioline Code: pr11073
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 10, No. 5, 2011, pp. 603-609

 en Effect of Dietary Intake of Fermented Seeds of Parkia biglobosa check for this species in other resources (Jacq) Benth (African Locust Bean) on Hypertension in Bogou and Goumou-kope Areas of Togo
Ognatan, K; Adi, K; Lamboni, C; Damorou, J-M; Aklikokou, KA; Gbeassor, M & Guilland, J-C


Purpose: To identify the possible effect of the consumption of fermented seeds of Parkia biglobosa (Jack) Benth, Mimosaceae (African locust bean) by humans on the prevention of hypertension.
Methods: Two types of populations in Togo were identified and compared: one type was in a region (Bogou) where the condiment (Parkia biglobosa seeds) is highly consumed and the other people do not eat it at all (Goumou-kope). Anthropometrical, clinical and biochemical analyses were investigated in both target groups.
Results: Significantly decreased blood pressure and heart beat were detected in the group of people living in Bogou’s region when compared to the non-consumption group of Goumou-kope (p <0.001). Magnesium level was significantly increased in the Bogou group compared to that in the second group (p <0.0001). Lower levels of low density lipoprotein-cholesterol (91± 36 vs. 110 ± 44 mg/dL, p = 0.01), triglycerides (111 ± 6 vs. 129 ± 6 mg/dL, p = 0.028), and higher levels of high density lipoproteincholesterol (63 ± 2 vs. 48 ± 3 mg/dL, p <0.001) were observed in subjects who regularly consummed P. biglobosa fermented seeds. Furthermore, plasma glucose concentration was significantly lower in Bogou group than in Goumou-kope (68 ± 16 vs. 76 ± 15 mg/dL (p <0.001).
Conclusion: The results of the present study demonstrate that fermented seeds of Parkia biglobosa exert an anti-hypertension effect.

Blood minerals, Plasma lipids, Antihypertensive, Parkia biglobosa seeds

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