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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 10, No. 5, 2011, pp. 671-680
Bioline Code: pr11081
Full paper language: English
Document type: Review Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 10, No. 5, 2011, pp. 671-680

 en Antiprotozoal Activity of α,β-Unsaturated θ-Lactones: Promising Compounds for the Development of New Therapeutic Alternatives
Wilson, Cardona G & Jairo, Saez V

Abstract

The parasite resistance and side effects of drugs used to treat protozoal diseases have led to the search for new therapies, both natural and synthetic. Studies have shown that various θα, β-unsaturated θ- lactones displayed high antiprotozoal activity and thus are promising compounds for new drug discovery and development. These compounds and their activity are examined in this review.

Keywords
Lactones, Pyrones, Antiparasitic, Antiprotozoal, Leishmania, Malaria, Chagas, Plasmodium falciparum, Tripanosoma cruzi

 
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