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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 10, No. 6, 2011, pp. 747-753
Bioline Code: pr11089
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 10, No. 6, 2011, pp. 747-753

 en Photoprotective Effects of Hydroalcohol Tagetes Erectus check for this species in other resources Extract Against UV-Induced Oxidative Damage in Mice
Sachdeva, Monika; Kharya, Murli Dhar; Aljarbou, Ahmed & Katyal, Taruna

Abstract

Purpose: To investigate the effects of topical application of Tagetes Erectus hydroalcohol extract as a dermal antioxidant agent and evaluate its capacity to prevent ultraviolet (UV)–induced oxidative damage.
Methods: The plant flower was extracted with aqueous ethanol (60 %). Female Lacca mice were divided into five groups of 24 animals each. Group I was un-irradiated control (neither UV exposure nor any treatment received). Group II was irradiated control and received 5 min UV exposure twice a day. Groups III, 1V and V received both UV exposure and treatment of different concentrations of the extract, 4 h. prior to UV exposure. The degree of protection was quantified using biochemical tests (lipid peroxidation and glutathione level) and histopathological assessment.
Results: The results showed that 2% topical extract treatment reduced the effect of UV light-induced photoaging on mice skin by decreasing malondialdehyde (MDA) level by up to 50 % and increasing glutathione (GSH) level 3-fold (p<0.01) compared to UV-irradiated control group. Histopathological evaluation also indicated a photo-protective effect on the extract-treated mice skin as no signs of histological changes were seen after UV exposure.
Conclusion: Topical application of T. erectus has a potential for preventing oxidative damage by UV irradiation.

Keywords
T.erectus , Photo-ageing, skin wrinkles, Antioxidants, Oxidative damage, UV radiation

 
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