Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 11, No. 2, 2012, pp. 177-183
Bioline Code: pr12022
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 11, No. 2, 2012, pp. 177-183
© Copyright - 2012 Tropical Journal of Pharmaceutical Research
Preparation and Characterization of Sugar Cane Wax Microspheres Containing Indomethacin|
Gowda, DV; Hemant, KSY; Moin, Afrasim & ShivaKumar, HG
Purpose: To formulate and characterize indomethacin (IM) microspheres prepared with sugar cane wax microsperes.
Methods: Microspheres were prepared by melt-emulsified dispersion and cooling-induced solidification method. The microspheres were characterized by scanning electron microscopy (SEM) and differntial scanning calorimetry (DSC) as well as for drug loading, and in vitro and in vivo release in albino sheeps.
Results: SEM images showed that the microspheres were spherical in shape and more than 98.0 % of the isolated microspheres were in the size range 345 - 360 µm. The Cmax, Tmax, AUCO - 24 and T1/2
values were 2123 ± 30 ng/ml, 3.1 h, 9734 ± 126 ng/ml h−1, and 2.68 ± 0.03 h−1 for the reference product,
Microcid® SR, and 1989 ± 26 ng/ml, 3.0 h, 8013 ± 79 ng/ml h−1, and 2.79 ± 0.12 h−1, respectively, for the
Conclusion: Based on this study, it can be concluded that the developed indomethacin-loaded wax
microsheres and Microcid® SR capsule are bioequivalent in terms of rate and extent of absorption.
Indomethacin, Bioavailability, Controlled release Sugarcane wax, Release kinetics
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