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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 11, No. 3, 2012, pp. 437-444
Bioline Code: pr12053
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 11, No. 3, 2012, pp. 437-444

 en Effect of Boiling on the Cytotoxic and Antioxidant Properties of Aqueous Fruit Extract of Desert Date, Balanites aegyptiaca check for this species in other resources (L) Delile
Amadou, Issoufou; Le, Guo-Wei & Shi, Yong-Hui

Abstract

Purpose: To evaluate the effect of boiling on in vitro bioactivities potency of Balanites aegyptiaca check for this species in other resources L. Delile (desert date) aqueous extract, a juice used traditionally for cooking ready-to-eat millet flour paste.
Methods: Desert date fruits (1.5 kg) were soaked in water (1:2, fruit: water) for 24 h and sieved. The extract was divided into two parts - fresh extract (Fext) and boiled extract (Bext) which was obtained by boiling a portion of Fext for 10 min. The extracts were tested against the stomach cancer cell line SGC7901 and for antioxidant activity by 1,1-diphenyl-2-icrylhydrazyl DPPH, hydroxyl radical and ferric reducing power methods.
Results: Both fresh extract (Fext) and boiled extract (Bext) exhibited pronounced antioxidant activity with DPPH values of 88.2 and 97.0 %, respectively, at hydroxyl radical concentration of 5 mg/ml. The extract contained a significant amount of vitamin C (42.3 and 38.9 mg/100 g for Fext and Bext, respectively). Boiling had significant effect (p<0.01) on its antioxidant activity and also on its cytotoxic effect (56 % and 44 % dead cells respectively for Bext and Fext at respectively, at a concentration of 200 μg/ml).
Conclusion: It is concluded that B. aegyptiaca aqueous extracts have remarkable cytotoxic activity against stomach cancer cell SGC7901.

Keywords
Balanites aegyptiaca, Desert date, Cytotoxicity, Antioxidant activity, Stomach cancer cell line, DPPH radical

 
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