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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 11, No. 3, 2012, pp. 445-453
Bioline Code: pr12054
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 11, No. 3, 2012, pp. 445-453

 en Artemisia Annua check for this species in other resources L. Infusion Consumed Once a Week Reduces Risk of Multiple Episodes of Malaria: A Randomised Trial in a Ugandan Community
Ogwang, Patrick E; Ogwal, Jasper O; Kasasa, Simon; Olila, Deogratius; Ejobi, Francis; Kabasa, David & Obua, Celestino

Abstract

Purpose: To evaluate the protective effect of Artemisia annua check for this species in other resources infusion against malaria in a community that uses it as herbal ‘tea’ for malaria prevention.
Methods: 132 flower farm workers who met the study inclusion criteria and were not yet using A. annua infusion were randomized either to A. annua or placebo groups in the ratio of 1:1. Treatments were administered once a week under direct observation to participants. Malaria episodes were documented over a 9-month period while adverse effects were documented over 12 months.
Results: A. annua herbal ‘tea’ significantly reduced the risk of suffering more than one episode of malaria in nine months by 55 % (12/67 vs 26/65, p = 0.005 No participant experienced any serious adverse effect although bitter taste was the most common side effect of the infusion.
Conclusion: Artemisia annua infusion consumed once a week was effective in preventing multiple episodes of malaria in humans living in malaria endemic areas. However, its bitter taste and the risk of development of malaria parasite resistance to the artemisinin contained in it remain major challenges for its use in the mass control of malaria.

Keywords
Artemisia annua, Herbal tea, Community, Malaria prevention

 
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