Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 11, No. 5, 2012, pp. 695-702
Bioline Code: pr12082
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 11, No. 5, 2012, pp. 695-702
© Copyright 2012 - Tropical Journal of Pharmaceutical Research
Formulation and Optimization of Celecoxib-Loaded Microspheres Using Response Surface Methodology|
Shahzad, MK; Ubaid, M & Murtaza, G
To employ response surface methodology (RSM) for statistical optimization of formulation
factors in the preparation of celecoxib-loaded microspheres.
Celecoxib microspheres were prepared by solvent evaporation method.
Biodegradable/biocompatible polymers, Eudragit L-100 and polyvinyl pyrrolidone, were used in the
encapsulation procedure. A central composite design employing Stat-Ease design Expert®, version
7.0.3 having a unit value of α was used according to reference protocols to assess the influence of two
independent variables (i.e., the concentration of the two polymers used) on four dependent variables
(i.e., recovery, encapsulation efficiency and % drug releasred). The polymers used were Eudragit-L100
(X1) and polyvinyl pyrrolidone (X2). The microspheres were characterized for size, shape, recovery (%),
entrapment efficiency and drug release.
The recovered total weight of microspheres ranged between 49.4 ± 3.1 and 91.1 ± 4.8 %, and
it decreased with increase in the concentration of PVP. Entrapment efficiency was in the range of 54.1 ±
2.9 to 95.6 ± 3.7 %, and was also dependent on polymer concentration. The release of celecoxib
increased with decrease in Eudragit L-100 concentration and increase in PVP concentration. Higuchi
model was the best-fit drug release from all the formulations. Korsemeyer-Peppas release exponent (n)
indicates that drug release pattern was non-Fickian diffusion.
Using RSM, it is possible to optimize the drug release properties of celecoxib-loaded
microspheres. A celecoxib-loaded microsphere formulation with optimum recovery, entrapment
efficiency and release behavior was proposed.
Celecoxib, Eudragit L-100, Polyvinyl pyrrolidone, Response surface methodology, Microspheres.
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