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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 11, No. 5, 2012, pp. 713-719
Bioline Code: pr12084
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 11, No. 5, 2012, pp. 713-719

 en Development and Evaluation of Floating Microspheres of Curcumin
Kumar, Kapil & Rai, AK

Abstract

Purpose: To prepare and evaluate floating microspheres of curcumin for prolonged gastric residence time and increased drug bioavailability.
Methods: Floating microsphere were prepared by emulsion solvent diffusion method, using hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios. Ethanol/dichloromethane blend was used as solvent in a ratio of 1:1. The floating microspheres were evaluated for flow properties, particle size, incorporation efficiency, as well as in-vitro floatability and drug release. The shape and surface morphology of the microspheres were characterised by optical and scanning electron microscopy.
Result: The floating microspheres showed particle size, buoyancy, drug entrapment efficiency and yield in the ranges of 251 - 387 μm, 74.6 - 90.6 %, and 72.6 - 83.5 %, and 45.5 - 82.0 %, respectively. Maximum drug release after 20 h was 47.1, 55.7, 69.4 and 81.3 % for formulations F1, F2, F3 and F4, respectively. Scanning electron micrographs indicate pores both on the surface and interior of the microspheres.
Conclusion: The developed curcumin microsphere system is a promising floating drug delivery system for oral sustained administration of curcumin.

Keywords
Gastro-retentive, Sustained release, Curcumin, Floating microspheres; Ethyl cellulose, Hydroxylpropyl methylcellulose, Eudragit

 
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