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Development and Evaluation of Floating Microspheres of Curcumin
Kumar, Kapil & Rai, AK
Abstract
Purpose:
To prepare and evaluate floating microspheres of curcumin for prolonged gastric residence
time and increased drug bioavailability.
Methods:
Floating microsphere were prepared by emulsion solvent diffusion method, using
hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios.
Ethanol/dichloromethane blend was used as solvent in a ratio of 1:1. The floating microspheres were
evaluated for flow properties, particle size, incorporation efficiency, as well as in-vitro floatability and
drug release. The shape and surface morphology of the microspheres were characterised by optical
and scanning electron microscopy.
Result:
The floating microspheres showed particle size, buoyancy, drug entrapment efficiency and
yield in the ranges of 251 - 387 μm, 74.6 - 90.6 %, and 72.6 - 83.5 %, and 45.5 - 82.0 %, respectively.
Maximum drug release after 20 h was 47.1, 55.7, 69.4 and 81.3 % for formulations F1, F2, F3 and F4,
respectively. Scanning electron micrographs indicate pores both on the surface and interior of the
microspheres.
Conclusion:
The developed curcumin microsphere system is a promising floating drug delivery system
for oral sustained administration of curcumin.
Keywords
Gastro-retentive, Sustained release, Curcumin, Floating microspheres; Ethyl cellulose, Hydroxylpropyl methylcellulose, Eudragit
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