Development and Evaluation of Floating Microspheres of Curcumin|
Kumar, Kapil & Rai, AK
To prepare and evaluate floating microspheres of curcumin for prolonged gastric residence
time and increased drug bioavailability.
Floating microsphere were prepared by emulsion solvent diffusion method, using
hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios.
Ethanol/dichloromethane blend was used as solvent in a ratio of 1:1. The floating microspheres were
evaluated for flow properties, particle size, incorporation efficiency, as well as in-vitro floatability and
drug release. The shape and surface morphology of the microspheres were characterised by optical
and scanning electron microscopy.
The floating microspheres showed particle size, buoyancy, drug entrapment efficiency and
yield in the ranges of 251 - 387 μm, 74.6 - 90.6 %, and 72.6 - 83.5 %, and 45.5 - 82.0 %, respectively.
Maximum drug release after 20 h was 47.1, 55.7, 69.4 and 81.3 % for formulations F1, F2, F3 and F4,
respectively. Scanning electron micrographs indicate pores both on the surface and interior of the
The developed curcumin microsphere system is a promising floating drug delivery system
for oral sustained administration of curcumin.
Gastro-retentive, Sustained release, Curcumin, Floating microspheres; Ethyl cellulose, Hydroxylpropyl methylcellulose, Eudragit